Here is a simple example for those getting started with Python GUI Programming, wxWidgets, and the wxPython Bindings.
This small program will display a Frame and the static text "Hello World!", positioned with a BoxSixer.
Output looks like this:

#!/usr/bin/env python
import wx
class Application(wx.Frame):
def __init__(self, parent):
wx.Frame.__init__(self, parent, -1, 'My GUI', size=(300, 200))
panel = wx.Panel(self)
sizer = wx.BoxSizer(wx.VERTICAL)
panel.SetSizer(sizer)
txt = wx.StaticText(panel, -1, 'Hello World!')
sizer.Add(txt, 0, wx.TOP|wx.LEFT, 20)
self.Centre()
self.Show(True)
app = wx.App(0)
Application(None)
app.MainLoop()